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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000403304':
TSPY1 - Testis-specific Y-encoded protein 1; May be involved in sperm differentiation and proliferation.
[a.k.a. TSPY10, TSPY8, TSPY3]
2) '9606.ENSP00000372547':
SRY - Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partia [...]
[a.k.a. JQ811905, 2GZK, NM_003140.2]
3) '9606.ENSP00000368370':
WT1 - Wilms tumor protein; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has [...]
[a.k.a. ENST00000527882, NP_001185480.1, WT1-206]
4) '9606.ENSP00000497217':
FOXL2 - Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic [...]
[a.k.a. 668, R-HSA-2990846, R-HSA-3108232]
5) '9606.ENSP00000364591':
TSPYL2 - Testis-specific Y-encoded-like protein 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
[a.k.a. NP_071400, ENST00000578306.5, CTCL]
6) '9606.ENSP00000155093':
ZFY - Zinc finger Y-chromosomal protein; Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.
[a.k.a. ENSP00000368481, NM_003411.4, Zinc finger protein Y-linked]
7) '9606.ENSP00000371711':
DMRT1 - Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and prom [...]
[a.k.a. XP_006716795.1, ENST00000382276.7, ENST00000382276]
8) '9606.ENSP00000221496':
AMH - Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
[a.k.a. P03971, R-HSA-162582, 268]
9) '9606.TTTY1':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
10) '9606.ENSP00000245479':
SOX9 - Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity).
[a.k.a. ENSG00000125398, 6662, R-HSA-162582]
