Your Input: | |||||
KIR2DL4 | |||||
PRSS57 | |||||
HBG1 | |||||
SPECC1 | |||||
ASZ1 | |||||
SDSL | |||||
SH2D3A | |||||
MRPL58 | |||||
CDK2AP1 | |||||
SPI1 |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASZ1 | SH2D3A | ENSP00000284629 | ENSP00000245908 | Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the p [...] | SH2 domain-containing protein 3A; May play a role in JNK activation. | 0.713 |
KIR2DL4 | MRPL58 | ENSP00000339634 | ENSP00000301585 | Killer cell immunoglobulin-like receptor 2DL4; Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD [...] | Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. | 0.723 |
MRPL58 | KIR2DL4 | ENSP00000301585 | ENSP00000339634 | Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. | Killer cell immunoglobulin-like receptor 2DL4; Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD [...] | 0.723 |
MRPL58 | SPECC1 | ENSP00000301585 | ENSP00000261503 | Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. | Cytospin-B; Sperm antigen with calponin homology and coiled-coil domains 1. | 0.714 |
PRSS57 | SH2D3A | ENSP00000482358 | ENSP00000245908 | Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues ; Belongs to the peptidase S1 family. | SH2 domain-containing protein 3A; May play a role in JNK activation. | 0.997 |
PRSS57 | SPECC1 | ENSP00000482358 | ENSP00000261503 | Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues ; Belongs to the peptidase S1 family. | Cytospin-B; Sperm antigen with calponin homology and coiled-coil domains 1. | 0.875 |
SH2D3A | ASZ1 | ENSP00000245908 | ENSP00000284629 | SH2 domain-containing protein 3A; May play a role in JNK activation. | Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the p [...] | 0.713 |
SH2D3A | PRSS57 | ENSP00000245908 | ENSP00000482358 | SH2 domain-containing protein 3A; May play a role in JNK activation. | Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues ; Belongs to the peptidase S1 family. | 0.997 |
SH2D3A | SPECC1 | ENSP00000245908 | ENSP00000261503 | SH2 domain-containing protein 3A; May play a role in JNK activation. | Cytospin-B; Sperm antigen with calponin homology and coiled-coil domains 1. | 0.912 |
SPECC1 | MRPL58 | ENSP00000261503 | ENSP00000301585 | Cytospin-B; Sperm antigen with calponin homology and coiled-coil domains 1. | Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. | 0.714 |
SPECC1 | PRSS57 | ENSP00000261503 | ENSP00000482358 | Cytospin-B; Sperm antigen with calponin homology and coiled-coil domains 1. | Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues ; Belongs to the peptidase S1 family. | 0.875 |
SPECC1 | SH2D3A | ENSP00000261503 | ENSP00000245908 | Cytospin-B; Sperm antigen with calponin homology and coiled-coil domains 1. | SH2 domain-containing protein 3A; May play a role in JNK activation. | 0.912 |