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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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⤓ Mapping
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1) '9606.ENSP00000480703':
SLC46A1 - Proton-coupled folate transporter; Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. Belongs to the major facilitator superfamily. SLC46A family.
[a.k.a. NX_Q96NT5, 113235, R-HSA-196854]
2) '9606.ENSP00000252723':
EPO - Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.
[a.k.a. R-HSA-162582, 2056, R-HSA-9027284]
3) '9606.LINC00240':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
4) '9606.ENSP00000471894':
HAMP - Hepcidin-20; Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. Belongs to the hepcidin family.
[a.k.a. CHEMBL3989381, NP_066998.1, PLTR]
5) '9606.ENSP00000255030':
CRP - C-reactive protein(1-205); Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
[a.k.a. R-HSA-173623, CCDS30911, CRP-207]
6) '9606.ENSP00000376197':
TFRC - Transferrin receptor protein 1, serum form; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with tra [...]
[a.k.a. TFRC-207, 7037, TFRC-206]
7) '9606.ENSP00000498715':
INTS14 - Integrator complex subunit 14; Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing; Belongs to the INTS14 family.
[a.k.a. R-HSA-6807505, uc002ape.5, AK296134]
8) '9606.ENSP00000382804':
ODF3B - Outer dense fiber of sperm tails 3B.
[a.k.a. ENSP00000384310, ENSP00000384012, uc003bmh.2]
9) '9606.ENSP00000377725':
ZKSCAN5 - Zinc finger protein with KRAB and SCAN domains 5; May be involved in transcriptional regulation.
[a.k.a. ENST00000394170, NP_001305011, NP_055384.1]
10) '9606.ENSP00000348170':
HP - Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
[a.k.a. HP-213, J3QR68, ENST00000576168.6]
