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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000370625':
POLR2B - DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...]
[a.k.a. R-HSA-162587, R-HSA-6781823, NM_000938]
2) '9606.ENSP00000381231':
CBS - Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
[a.k.a. CBS-213, CBS-201, XP_016883979.1]
3) '9606.ENSP00000360797':
CARD9 - Caspase recruitment domain-containing protein 9; Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in ac [...]
[a.k.a. A0A024R8I4, caspase recruitment domain family, member 9, ENSP00000493113]
4) '9606.ENSP00000485527':
CBSL - Cystathionine beta-synthase like.
[a.k.a. NM_001354015, UPI0000169740, NP_001340937.1]
5) '9606.ENSP00000003100':
CYP51A1 - Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]
[a.k.a. CP51, ENST00000496998, B2RAI4]
6) '9606.ENSP00000482202':
PIGW - Phosphatidylinositol-glycan biosynthesis class W protein; Required for the transport of GPI-anchored proteins to the plasma membrane. Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity). Belongs to the PIGW family.
[a.k.a. ENST00000619326.1, PIGW-205, ENSG00000277161]
7) '9606.ENSP00000219240':
DHODH - Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
[a.k.a. NP_001352.2, 4LS1, 4JTT]
8) '9606.ENSP00000356548':
LTV1 - Protein LTV1 homolog; LTV1 ribosome biogenesis factor.
[a.k.a. 6G53, LTV1 ribosome biogenesis factor, FLJ14909]
9) '9606.NAPA-AS1':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
10) '9606.ENSP00000263326':
IL37 - Interleukin-37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation; Belongs to the IL-1 family.
[a.k.a. IL1RP1, IL37-201, NP_775294.1]
