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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000294304':
LRP5 - Low-density lipoprotein receptor-related protein 5; Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone [...]
[a.k.a. LDL receptor related protein 5, UPI0001F78393, EVR1]
2) '9606.ENSP00000348163':
PLS3 - Plastin-3; Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.
[a.k.a. NM_001282338.2, M34427, ENSG00000102024]
3) '9606.ENSP00000433208':
PTH - Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
[a.k.a. R-HSA-388396, R-HSA-162582, R-HSA-373080]
4) '9606.ENSP00000297268':
COL1A2 - Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family.
[a.k.a. R-HSA-202733, P08123, R-HSA-6806834]
5) '9606.ENSP00000357255':
BGLAP - Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
[a.k.a. bone gamma-carboxyglutamate (gla) protein, BC113432, Gamma-carboxyglutamic acid-containing protein]
6) '9606.ENSP00000301691':
SOST - Sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
[a.k.a. NP_079513, R-HSA-162582, R-HSA-195721]
7) '9606.ENSP00000225964':
COL1A1 - Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).
[a.k.a. Collagen type I alpha 1 chain, COL1A1-206, R-HSA-202733]
8) '9606.ENSP00000381775':
TNFSF11 - Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...]
[a.k.a. BC074823, OPGL, CD254]
9) '9606.hsa-miR-550a-3p':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
10) '9606.ENSP00000297350':
TNFRSF11B - Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
[a.k.a. ENST00000517352, NP_002537.3, ENSP00000297350]
