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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000392423':
RELN - Reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity); Belongs to the reel [...]
[a.k.a. 5649, AC006316, ENST00000428762]
2) '9606.ENSP00000225964':
COL1A1 - Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).
[a.k.a. Collagen type I alpha 1 chain, COL1A1-206, R-HSA-202733]
3) '9606.ENSP00000297350':
TNFRSF11B - Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
[a.k.a. ENST00000517352, NP_002537.3, ENSP00000297350]
4) '9606.ENSP00000378534':
MEPE - Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation. Belongs to the PF07175/osteoregulin family.
[a.k.a. CCDS54776, NM_001184695.1, NP_001171623.1]
5) '9606.ENSP00000372295':
GJB2 - Gap junction beta-2 protein; Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
[a.k.a. AY275650, XP_011533351.1, MH234118]
6) '9606.ENSP00000328181':
NOG - Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6.
[a.k.a. U31202, Q13253, R-HSA-162582]
7) '9606.ENSP00000496044':
POLR1C - DNA-directed RNA polymerases I and III subunit RPAC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
[a.k.a. POLR1C-207, KF458158, ENST00000645141.1]
8) '9606.ENSP00000245451':
BMP4 - Bone morphogenetic protein 4; Induces cartilage and bone formation. Also acts in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).
[a.k.a. R-HSA-2129379, CAD61909.1, CAD61876.1]
9) '9606.ENSP00000254722':
SERPINF1 - Pigment epithelium-derived factor; Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
[a.k.a. ENST00000254722.8, ENST00000573770, Q13236]
10) '9606.LINC01482':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -