Your Input: | |||||
PSAP | |||||
ARSA | |||||
SUMF1 | |||||
ARSB | |||||
GALC | |||||
IDUA | |||||
SGSH | |||||
IDS | |||||
PSMA7 | |||||
GLA |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARSA | ARSB | ENSP00000216124 | ENSP00000264914 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | 0.950 |
ARSA | GALC | ENSP00000216124 | ENSP00000261304 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon; Belongs to the glycosyl hydrolase 59 family. | 0.985 |
ARSA | GLA | ENSP00000216124 | ENSP00000218516 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family. | 0.974 |
ARSA | IDUA | ENSP00000216124 | ENSP00000247933 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | alpha-L-iduronidase. | 0.734 |
ARSA | PSAP | ENSP00000216124 | ENSP00000378394 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Saposin-B-Val; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of [...] | 0.913 |
ARSA | SUMF1 | ENSP00000216124 | ENSP00000272902 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3- oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Belongs to the sulfatase-modifying factor family. | 0.957 |
ARSB | ARSA | ENSP00000264914 | ENSP00000216124 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | 0.950 |
ARSB | IDUA | ENSP00000264914 | ENSP00000247933 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | alpha-L-iduronidase. | 0.973 |
ARSB | SUMF1 | ENSP00000264914 | ENSP00000272902 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3- oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Belongs to the sulfatase-modifying factor family. | 0.947 |
GALC | ARSA | ENSP00000261304 | ENSP00000216124 | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon; Belongs to the glycosyl hydrolase 59 family. | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | 0.985 |
GALC | GLA | ENSP00000261304 | ENSP00000218516 | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon; Belongs to the glycosyl hydrolase 59 family. | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family. | 0.976 |
GALC | PSAP | ENSP00000261304 | ENSP00000378394 | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon; Belongs to the glycosyl hydrolase 59 family. | Saposin-B-Val; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of [...] | 0.938 |
GLA | ARSA | ENSP00000218516 | ENSP00000216124 | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family. | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | 0.974 |
GLA | GALC | ENSP00000218516 | ENSP00000261304 | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family. | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon; Belongs to the glycosyl hydrolase 59 family. | 0.976 |
GLA | PSAP | ENSP00000218516 | ENSP00000378394 | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family. | Saposin-B-Val; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of [...] | 0.776 |
IDS | IDUA | ENSP00000339801 | ENSP00000247933 | Iduronate 2-sulfatase 14 kDa chain; Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. | alpha-L-iduronidase. | 0.981 |
IDS | SUMF1 | ENSP00000339801 | ENSP00000272902 | Iduronate 2-sulfatase 14 kDa chain; Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3- oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Belongs to the sulfatase-modifying factor family. | 0.886 |
IDUA | ARSA | ENSP00000247933 | ENSP00000216124 | alpha-L-iduronidase. | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | 0.734 |
IDUA | ARSB | ENSP00000247933 | ENSP00000264914 | alpha-L-iduronidase. | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | 0.973 |
IDUA | IDS | ENSP00000247933 | ENSP00000339801 | alpha-L-iduronidase. | Iduronate 2-sulfatase 14 kDa chain; Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. | 0.981 |