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DISEASES
The following proteins in
Homo sapiens
appear to match your input.
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1) '9606.ENSP00000489407':
SHANK3 - SH3 and multiple ankyrin repeat domains protein 3; Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex [...]
[a.k.a. ENST00000445220.5, NP_001358973.1, NM_033517.1]
2) '9606.KIZ-AS1':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
3) '9606.ENSP00000370483':
NLGN4X - Neuroligin-4, X-linked; Putative neuronal cell surface protein involved in cell-cell- interactions; Belongs to the type-B carboxylesterase/lipase family.
[a.k.a. XP_016885182.1, XM_017029693.1, XM_005274565]
4) '9606.ENSP00000500990':
SNCA - Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]
[a.k.a. AAA16117.1, SNCA-206, XM_011532203]
5) '9606.ENSP00000351591':
NLGN3 - Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity); Belongs to the type-B carboxylesterase/lipase family.
[a.k.a. NLGN3-203, Neuroligin, BC051715]
6) '9606.ENSP00000349945':
OR5B17 - Olfactory receptor 5B17; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
[a.k.a. R-HSA-388396, CCDS31548.1, R-HSA-162582]
7) '9606.ENSP00000395535':
MECP2 - Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC).
[a.k.a. XM_011531166, MRXSL, MECP2-224]
8) '9606.ENSP00000359506':
FMR1 - Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export (By similarity). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Stabilizes the scaffolding postsyna [...]
[a.k.a. L19486, ENST00000334557, LRG_762]
9) '9606.ENSP00000270349':
SLC6A3 - Sodium-dependent dopamine transporter; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
[a.k.a. DAT1, AF306563, AAA35770.1]
10) '9606.ENSP00000324270':
OXTR - Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
[a.k.a. R-HSA-388396, 5021, OT-R]
