Your Input: | |||||
TNNI2 | |||||
MYH3 | |||||
MYBPC1 | |||||
TPM2 | |||||
FBN2 | |||||
TNNT3 | |||||
WNK4 | |||||
PIEZO2 | |||||
MYH8 | |||||
ECEL1 |
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FBN2 | MYH3 | ENSP00000424571 | ENSP00000464317 | Fibrillin-2 C-terminal peptide; [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Belongs to the fibrillin family. | Myosin-3; Muscle contraction. | 0.753 |
MYBPC1 | MYH3 | ENSP00000400908 | ENSP00000464317 | Myosin-binding protein C, slow-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin-3; Muscle contraction. | 0.820 |
MYBPC1 | MYH8 | ENSP00000400908 | ENSP00000384330 | Myosin-binding protein C, slow-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin-8; Muscle contraction. | 0.792 |
MYBPC1 | TNNI2 | ENSP00000400908 | ENSP00000371336 | Myosin-binding protein C, slow-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.754 |
MYBPC1 | TNNT3 | ENSP00000400908 | ENSP00000370975 | Myosin-binding protein C, slow-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.744 |
MYH3 | FBN2 | ENSP00000464317 | ENSP00000424571 | Myosin-3; Muscle contraction. | Fibrillin-2 C-terminal peptide; [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Belongs to the fibrillin family. | 0.753 |
MYH3 | MYBPC1 | ENSP00000464317 | ENSP00000400908 | Myosin-3; Muscle contraction. | Myosin-binding protein C, slow-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | 0.820 |
MYH3 | MYH8 | ENSP00000464317 | ENSP00000384330 | Myosin-3; Muscle contraction. | Myosin-8; Muscle contraction. | 0.772 |
MYH3 | TNNI2 | ENSP00000464317 | ENSP00000371336 | Myosin-3; Muscle contraction. | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.974 |
MYH3 | TNNT3 | ENSP00000464317 | ENSP00000370975 | Myosin-3; Muscle contraction. | Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.965 |
MYH3 | TPM2 | ENSP00000464317 | ENSP00000496494 | Myosin-3; Muscle contraction. | Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. | 0.959 |
MYH8 | MYBPC1 | ENSP00000384330 | ENSP00000400908 | Myosin-8; Muscle contraction. | Myosin-binding protein C, slow-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | 0.792 |
MYH8 | MYH3 | ENSP00000384330 | ENSP00000464317 | Myosin-8; Muscle contraction. | Myosin-3; Muscle contraction. | 0.772 |
MYH8 | TNNI2 | ENSP00000384330 | ENSP00000371336 | Myosin-8; Muscle contraction. | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.852 |
MYH8 | TNNT3 | ENSP00000384330 | ENSP00000370975 | Myosin-8; Muscle contraction. | Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.865 |
MYH8 | TPM2 | ENSP00000384330 | ENSP00000496494 | Myosin-8; Muscle contraction. | Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. | 0.835 |
TNNI2 | MYBPC1 | ENSP00000371336 | ENSP00000400908 | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | Myosin-binding protein C, slow-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | 0.754 |
TNNI2 | MYH3 | ENSP00000371336 | ENSP00000464317 | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | Myosin-3; Muscle contraction. | 0.974 |
TNNI2 | MYH8 | ENSP00000371336 | ENSP00000384330 | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | Myosin-8; Muscle contraction. | 0.852 |
TNNI2 | TNNT3 | ENSP00000371336 | ENSP00000370975 | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.999 |