Disease-gene associations mined from literature

MARK3 disease associations

MARK3 [ENSP00000411397]

MAP/microtubule affinity-regulating kinase 3; Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.

Synonyms:  MARK3,  MARK3p,  hMARK3,  A2SY06,  B4DKN1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM