DISEASES

Disease-gene associations mined from literature

ARHGEF7 disease associations

ARHGEF7 [ENSP00000364893]

Rho guanine nucleotide exchange factor (GEF) 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons; Pleckstrin homology domain containing

Synonyms:  ARHGEF7,  ARHGEF7p,  hARHGEF7,  A0A024RDY9,  ARHGEF7-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM