BAX disease associations
BCL2-associated X protein; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis; Belongs to the Bcl-2 family.
Synonyms: BAX-001, BAX-002, BAX-003, BAX-004, BAX-005 ...