DISEASES

Disease-gene associations mined from literature

Literature on WASL

WASL [ENSP00000223023]

Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity); Wiskott-Aldrich Syndrome protein family

Synonyms:  WASL,  O00401,  WASL-001,  O00401p,  hO00401 ...

Linkouts:  STRING  Pharos