DISEASES

Disease-gene associations mined from literature

Literature on HRH2

HRH2 [ENSP00000366506]

Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity); Belongs to the G-protein coupled receptor 1 family.

Synonyms:  HRH2,  HRH2p,  hHRH2,  P25021,  P25021p ...

Linkouts:  STRING  Pharos  UniProt  OMIM