DISEASES

Disease-gene associations mined from literature

Literature on TRPS1

TRPS1 [ENSP00000379065]

Tricho-rhino-phalangeal syndrome type I protein; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes; GATA zinc finger domain containing

Synonyms:  TRPS1,  TRPS1p,  hTRPS1,  C9J6L7,  E5RFF3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM