DISEASES

Disease-gene associations mined from literature

Literature on CAMK2A

CAMK2A [ENSP00000381412]

Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298'. Activates FOXO3 transcriptional activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Synonyms:  CAMK2A,  CAMK2Ap,  hCAMK2A,  A8K161,  CAMK2A-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM