DISEASES

Disease-gene associations mined from literature

Literature on RCC1

RCC1 [ENSP00000362937]

Regulator of chromosome condensation 1; Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly.

Synonyms:  RCC1,  RCC1p,  hRCC1,  C9J3R0,  C9JMJ4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM