DISEASES

Disease-gene associations mined from literature

Literature on FGD2

FGD2 [ENSP00000274963]

FYVE, RhoGEF and PH domain-containing protein 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate (By similarity); Pleckstrin homology domain containing

Synonyms:  FGD2,  FGD2p,  hFGD2,  F8WEZ2,  H7BY95 ...

Linkouts:  STRING  Pharos  UniProt  OMIM