DISEASES

Disease-gene associations mined from literature

Literature on LGALS3

LGALS3 [ENSP00000254301]

Lectin, galactoside-binding, soluble, 3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells; Endogenous ligands

Synonyms:  LGALS3,  LGALS3p,  hLGALS3,  A0A024R693,  G3V3R6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM