DISEASES

Disease-gene associations mined from literature

Literature on VTCN1

VTCN1 [ENSP00000358470]

V-set domain containing T cell activation inhibitor 1; Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation; Immunoglobulin like domain containing

Synonyms:  VTCN1,  VTCN1p,  hVTCN1,  Q5T2L0,  Q7Z7D3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM