DISEASES

Disease-gene associations mined from literature

Literature on ZNF431

ZNF431 [ENSP00000308578]

Zinc finger protein 431; Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family.

Synonyms:  ZNF431,  ZNF431p,  hZNF431,  A0A024R7Q8,  M0QXY3 ...

Linkouts:  STRING  Pharos  UniProt