DISEASES

Disease-gene associations mined from literature

Literature on PVRL2

PVRL2 [ENSP00000252483]

Poliovirus receptor-related 2 (herpesvirus entry mediator B); Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein; Belongs to the nectin family.

Synonyms:  PVRL2,  PVRL2p,  hPVRL2,  K7EK87,  NECTIN2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM