DISEASES

Disease-gene associations mined from literature

Literature on YBX2

YBX2 [ENSP00000007699]

Germ cell-specific Y-box-binding protein; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).

Synonyms:  YBX2,  YBX2p,  hYBX2,  Q9Y2T7,  YBX2-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM