DISEASES

Disease-gene associations mined from literature

Literature on PTGER3

PTGER3 [ENSP00000349003]

Prostaglandin E receptor 3 (subtype EP3); Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).

Synonyms:  PTGER3,  PTGER3p,  hPTGER3,  B1AK19,  B2KKV4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM