DISEASES

Disease-gene associations mined from literature

Literature on ADRBK1

ADRBK1 [ENSP00000312262]

Adrenergic, beta, receptor kinase 1; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Synonyms:  ADRBK1,  ADRBK1p,  hADRBK1,  E9PRV7,  GRK2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM