DISEASES

Disease-gene associations mined from literature

Literature on HDAC6

HDAC6 [ENSP00000334061]

Histone deacetylase 6; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Synonyms:  HDAC6,  HDAC6p,  hHDAC6,  A0A024QZ26,  A6NDI8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM