DISEASES

Disease-gene associations mined from literature

Literature on FBXO11

FBXO11 [ENSP00000384823]

Protein arginine N-methyltransferase 9; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53; F-boxes other

Synonyms:  FBXO11,  FBXO11p,  hFBXO11,  B5MCV6,  C9IYF0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM