DISEASES

Disease-gene associations mined from literature

Literature on FADD

FADD [ENSP00000301838]

FAS-associating death domain-containing protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling; Death effector domain containing

Synonyms:  FADD,  Q13158,  Q6LCB0,  Q6LCG1,  GIG3 ...

Linkouts:  STRING  Pharos