DISEASES

Disease-gene associations mined from literature

Literature on CYP3A4

CYP3A4 [ENSP00000337915]

Cytochrome P450, family 3, subfamily A, polypeptide 4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro.

Synonyms:  CYP3A4,  CYP3A4p,  hCYP3A4,  B4DPQ5,  C9JBD2 ...

Linkouts:  STRING  Pharos