DISEASES

Disease-gene associations mined from literature

Literature on FBXO31

FBXO31 [ENSP00000310841]

F-box only protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor; Belongs to the FBXO31 family.

Synonyms:  FBXO31,  FBXO31p,  hFBXO31,  FBXO31-001,  FBXO31-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM