DISEASES

Disease-gene associations mined from literature

Literature on FASLG

FASLG [ENSP00000356694]

Tumor necrosis factor ligand superfamily member 6; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis; Belongs to the tumor necrosis factor family.

Synonyms:  FASLG,  P48023,  Q53ZZ1,  TNFSF6,  APT1LG1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM