Disease-gene associations mined from literature

Literature on SIRT3

SIRT3 [ENSP00000372191]

NAD-dependent protein deacetylase sirtuin-3, mitochondrial; NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels; Sirtuins

Synonyms:  SIRT3,  SIRT3p,  hSIRT3,  B7WNN4,  E9PIT6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM