DISEASES

Disease-gene associations mined from literature

Literature on PAM

PAM [ENSP00000306100]

Peptidyl-glycine alpha-amidating monooxygenase; Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

Synonyms:  A6NMH0,  D6R961,  D6RAQ2,  D6RCD5,  D6RDU2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM