DISEASES

Disease-gene associations mined from literature

Literature on RNF114

RNF114 [ENSP00000244061]

RING-type E3 ubiquitin transferase RNF114; E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis; Ring finger proteins

Synonyms:  RNF114,  RNF114p,  hRNF114,  H0UI65,  Q9Y508 ...

Linkouts:  STRING  Pharos  UniProt  OMIM