Disease-gene associations mined from literature

Literature on KMO

KMO [ENSP00000355517]

Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase); Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Synonyms:  KMO,  A0A024R3S9,  O15229,  O15229p,  hO15229 ...

Linkouts:  STRING  Pharos  UniProt  OMIM