DISEASES

Disease-gene associations mined from literature

Literature on IL1R2

IL1R2 [ENSP00000330959]

CD121 antigen-like family member B; Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors; CD molecules

Synonyms:  IL1R2,  IL1R2p,  hIL1R2,  C9JNR0,  P27930 ...

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