DISEASES

Disease-gene associations mined from literature

Literature on IL23R

IL23R [ENSP00000321345]

Interleukin 23 receptor; Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis; Belongs to the type I cytokine receptor family. Type 2 subfamily.

Synonyms:  IL23R,  IL23Rp,  hIL23R,  B6HY80,  D9N2T9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM