DISEASES

Disease-gene associations mined from literature

Literature on ADAM2

ADAM2 [ENSP00000265708]

Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing

Synonyms:  ADAM2,  ADAM2p,  hADAM2,  ADAM2-001,  ADAM2-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM