DISEASES

Disease-gene associations mined from literature

Literature on TDGF1

TDGF1 [ENSP00000296145]

Epidermal growth factor-like cripto protein CR1; GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

Synonyms:  TDGF1,  TDGF1p,  hTDGF1,  F5H1T8,  P13385 ...

Linkouts:  STRING  Pharos  UniProt  OMIM