DISEASES

Disease-gene associations mined from literature

Literature on MAP3K13

MAP3K13 [ENSP00000265026]

Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Synonyms:  MAP3K13,  MAP3K13p,  hMAP3K13,  C9IYH2,  C9J4W2 ...

Linkouts:  STRING  Pharos