DISEASES

Disease-gene associations mined from literature

Literature on TOP2A

TOP2A [ENSP00000411532]

DNA topoisomerase II, alpha isozyme; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity); Topoisomerases

Synonyms:  TOP2A,  TOP2Ap,  hTOP2A,  J3KTB7,  J3QR57 ...

Linkouts:  STRING  Pharos