DISEASES

Disease-gene associations mined from literature

Literature on KALRN

KALRN [ENSP00000240874]

Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Synonyms:  KALRN,  C9IYX8,  C9IZQ6,  C9J1B4,  E7EUZ8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM