DISEASES

Disease-gene associations mined from literature

Literature on AEN

AEN [ENSP00000331944]

Interferon-stimulated 20 kDa exonuclease-like 1; Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis; Exonucleases

Synonyms:  AEN,  H0YMJ6,  PP12744,  Q8WTP8,  Q8WYW8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM