DISEASES

Disease-gene associations mined from literature

Literature on NETO2

NETO2 [ENSP00000455169]

Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2; Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).

Synonyms:  NETO2,  NETO2p,  hNETO2,  B7Z4I7,  Q8NC67 ...

Linkouts:  STRING  Pharos  UniProt  OMIM