DISEASES

Disease-gene associations mined from literature

Literature on PARP14

PARP14 [ENSP00000418194]

ADP-ribosyltransferase diphtheria toxin-like 8; ADP-ribosyltransferase. By mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation. Mono-ADP- ribosylates STAT6 (By similarity). Enhances STAT6-dependent transcription (By similarity). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation. Mono-ADP- ribosylates PARP9; Poly(ADP-ribose) polymerases

Synonyms:  PARP14,  PARP14p,  hPARP14,  H7C5R8,  Q460N5 ...

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