DISEASES

Disease-gene associations mined from literature

Literature on SENP6

SENP6 [ENSP00000402527]

Sentrin/SUMO-specific protease SENP6; Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination; Belongs to the peptidase C48 family.

Synonyms:  SENP6,  SENP6p,  hSENP6,  B3KMM0,  D6RG09 ...

Linkouts:  STRING  Pharos  UniProt  OMIM