Literature on PYHIN1
Pyrin and HIN domain-containing protein 1; Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells; Pyrin and HIN domain family
Synonyms: PYHIN1, PYHIN1p, hPYHIN1, Q6K0P9, X6RHR0 ...