DISEASES

Disease-gene associations mined from literature

Literature on SBNO2

SBNO2 [ENSP00000354733]

Strawberry notch homolog 2 (Drosophila); Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP- repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP- dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the proinflammatory cascade.

Synonyms:  SBNO2,  SBNO2p,  hSBNO2,  K7ES28,  Q9Y2G9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM