Disease-gene associations mined from literature

Literature on ZRANB1

ZRANB1 [ENSP00000352676]

Zinc finger Ran-binding domain-containing protein 1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family.

Synonyms:  ZRANB1,  ZRANB1p,  hZRANB1,  Q9UGI0,  ZRANB1-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM