DISEASES

Disease-gene associations mined from literature

Literature on ADAM15

ADAM15 [ENSP00000349436]

Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain; ADAM metallopeptidase domain containing

Synonyms:  ADAM15,  ADAM15p,  hADAM15,  Q13444,  MDC15 ...

Linkouts:  STRING  Pharos  UniProt  OMIM